Diagnosis of ES primarily occurred in non-Hispanic White males, which is consistent with ES's historical predilection for European ancestries and strikingly low incidence in populations of African descent.15 This is likely secondary to genetic germline variants that are protective for African Americans.43 However, there is a tumor dedifferentiation risk of ES in people of African descent, which may be a result of a specific genetic alteration within the EGR2 gene.44 Regardless, patient sex and race did not account for notable differences in mortality status. The gene discussed is EGR2; the disease is Ewing sarcoma.