BCR and B-cell chronic lymphocytic leukemia: mTOR inhibition also completely blocked AktS473 phosphorylation in primary CLL cells induced by short-term (soluble anti-IgM) and long-term (bead-bound anti-IgM) BCR crosslinking, a known mTORC1/2 pathway activator (Figure 2, I, J, and K), and significantly impaired cMYC induction upon long-term BCR stimulation by bead-bound anti-IgM (Figure 2, J and K).