Therefore, the increased AktS473 phosphorylation after FoxO1 induction in CLL cells might be caused by the cooperation of 2 mechanisms, i.e., (a) Rictor upregulation leading to direct increase of mTORC2 kinase activity responsible for AktS473 phosphorylation and (b) induced GAB1 levels leading to PI3K signaling amplification (23). Here, FOXO1 is linked to B-cell chronic lymphocytic leukemia.