Therefore, the increased AktS473 phosphorylation after FoxO1 induction in CLL cells might be caused by the cooperation of 2 mechanisms, i.e., (a) Rictor upregulation leading to direct increase of mTORC2 kinase activity responsible for AktS473 phosphorylation and (b) induced GAB1 levels leading to PI3K signaling amplification (23). This evidence concerns the gene RICTOR and B-cell chronic lymphocytic leukemia.