AKT1 and B-cell chronic lymphocytic leukemia: The pAktS473 was restored in MEC1 cells treated with ibrutinib in vitro, where after an initial drop in Akt phosphorylation, its levels were induced within 5 days (fold-change ~40 between day 1 versus day 5, P = 0.012; Figure 1, C and D), allowing us to study this phenotype in a CLL-derived cell line.