Uniform manifold approximation and projection (UMAP) visualization showed that Siglec-7 and -9 are exclusively expressed on immune cells (Figure 2, B and C), mainly on myeloid cells, including macrophages,and myeloid-derived suppressor cells (MDSCs), and sparsely expressed on CD4+ T and CD8+ T cells (Figure 2, B–E and Supplemental Figure 4) in castration-resistant PCa (CRPC) tumor tissues. This evidence concerns the gene CD8A and posterior cortical atrophy.