Participants with T1D were less insulin sensitive than the HC group (7.8 ± 2.6 vs. 14.3 ± 4.0 mg/kg/min, P < 0.0001) during hyperinsulinemic-euglycemic clamps, and the difference between the 2 groups remained similar in magnitude and significance after normalizing by lean mass and adjusting for steady -state insulin concentrations (Table 1). Here, INS is linked to type 1 diabetes mellitus.