GIP and Hyperglycemia: In agreement with the outcome of a recent study (47), we found that i.p. treatment of WT mice for 4 weeks with [D-Ala2]GIP (24 nmoles/kg per dose; 2 injections per day; injection times: 9 am and 6 pm) had no significant effect on STZ-induced hyperglycemia (Supplemental Figure 5).