Although IgG2 did not induce CDC of tumor cells, the formation of large IgG2 oligomers (Fig. 4), C1 binding (Fig. 5) and complement mediated lysis of DNP-labeled vesicles (Fig. 8) has been observed, albeit with less potency compared to IgG1 and IgG3. The gene discussed is IGHG3; the disease is neoplasm.