CDC of human Burkitt’s lymphoma RAJI and DAUDI cells by human anti-CD20 IgG-7D8 was comparably efficient for IgG1-7D8 (Fig. 1A) and IgG3-7D8 (Fig. 1C), whereas no CDC was induced by IgG2-7D8 (Fig. 1B) and was only detected at highest IgG concentrations in case of IgG4-7D8 without reaching the maximum value of IgG1-7D8 (Fig. 1D). Here, IGHG3 is linked to Burkitt lymphoma.