Even if such patients were non-exhaustively described in the literature, we also identified 49 IgP-treated patients with positive anti-IgA Abs, and without IgP-HS (Fig. 2, Table S6): 35 had CVID, seven had sIgA, two had undefined hypogammaglobulinaemia, two had hyper-IgM syndrome and one had combined IgG2/IgA deficiency (missing data: n = 2). This evidence concerns the gene CD79A and hyper-IgM syndrome.