In family A (Fig. 3a), the proband (III: 2) was diagnosed with ovarian cancer at the age of 64 and was found to be a carrier of a novel frameshift pathogenic variant NM_000534.5:c.2294_2295 del in the PMS1 gene (Fig. 2a, reference sequence NM_000534.5). The gene discussed is PMS1; the disease is ovarian carcinoma.