The 5-year HF rates were also lower than in the prior 2 comparisons (insulin versus GLP-1 RAs and insulin versus DPP-4Is), with the estimated 5-year HF rate reaching 28.1% (95% CI 27.7%‐28.5%) in the insulin group and 13.0% (95% CI 12.3%‐13.7%) in the SGLT2I group (Figure S4 in Multimedia Appendix 1). The gene discussed is INS; the disease is hydrops fetalis.