After adjusting for a broad list of confounders, patients receiving insulin were found to be associated with an 11.8% (95% CI 11.0%‐12.7%), 12.0% (95% CI 11.5%‐12.4%), and 15.1% (95% CI 14.3%‐16.0%) higher 5-year HF rate compared to those using GLP-1 RAs, DPP-4Is, and SGLT2Is, respectively. The gene discussed is INS; the disease is hydrops fetalis.