STAT3 and cancer: Notably, we noted that TME-related pathways [e.g., transforming growth factor (TGF)-β signaling, epithelial mesenchymal transition (EMT), and angiogenesis], and immune signatures [e.g., tumor necrosis factor (TNF)-α signaling via nuclear factor-kappa B (NF-κB), inflammatory response, and IL6–JAK–STAT3 signaling], were predominantly positively, rather than negatively, enriched in integrinScore-high groups across cancers.