BRAF and mesothelioma: In addition to abovementioned cancer types, we also extended our analysis to several other TCGA cancer types, and found that integrinScore was also tightly correlated with multiple known subtypes defined by genomic [e.g., B-Raf proto-oncogene (BRAF) mutation for THCA and somatic copy-number alteration (SCNA) for TGCT], transcriptomic [e.g., mRNA for KIRP and UCEC, miRNA for COADREAD and mesothelioma (MESO), and long non-coding RNA (lncRNA) for KIRC], epigenetic (e.g., methylation for THCA and SKCM), and histological (e.g., UCEC) features (Figure S5J–W).