Additionally,the Rho-ROCK pathway participates in the direct regulation of actin-bindingproteins, such as profilin, cofilin, and gelsolin, and may resultin the rearrangement of short actin mesh into thick actin fibers.54,56−59 Inhibition of ROCK was reported to attenuate cancer cell motility.60,61 The second molecular inhibitor, blebbistatin, bypasses the regulationvia RLC and acts directly by binding to the motor domain of a myosin-heavychain. The gene discussed is GSN; the disease is cancer.