OXTR and Anxiety: The function of OT is exemplified by studies performed in OT or OTR knockout (KO) mice, which reveal deficits in social memory (Ferguson et al., 2001) and social interaction (Pobbe et al., 2012) and increased anxiety and stress responses to psychogenic and specific physiological stimuli (Amico et al., 2004; Mantella et al., 2003).