Our previous studies have shown that ASO-mediated rescue of PV interneuron firing reduces seizures and prevents SUDEP in a model of Dravet syndrome (82); a similar phenotype may be observed in SCN8A DEE, where rescue of depolarization block prevents seizures and SUDEP. This evidence concerns the gene SCN8A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.