Similarly, synaptic transmission between PV interneurons and PCs is also impaired in Dravet syndrome, though unlike our findings in SCN8A DEE, intrinsic excitability deficits are restored in adult PV interneurons (21, 23). The gene discussed is SCN8A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.