In addition to disruptive SLC39A8 mutations, a common genetic variant in SLC39A8 (p.Ala391Thr) is associated with multiple phenotypic traits and disease risks, including reduced blood Mn (21), neurological outcomes (including childhood neurodevelopment and behavioral problems) (22), lower fgeneral cognitive function (23), greater risks for schizophrenia (24–26), greater gray matter volume in multiple brain regions (27), and notably, a protective effect against Parkinson’s disease (26). Here, SLC39A8 is linked to Parkinson disease.