AKT1 and cancer: Volcano plot analysis, as well as KEGG and GO biological process analyses of the proteomics data, revealed notable changes and enrichments in protein expression, pathways, and biological processes associated with the PI3K‐Akt signaling pathway, MAPK signaling pathway, EGFR tyrosine kinase inhibitor resistance, response to drug, integrin‐mediated signaling pathways, and cell‐cell adhesion mediated by integrins in cancer cells treated with PC‐conditioned medium alongside the TKI drug, as compared to the control group (Figures4A–C; Figures S4A–C, Supporting Information).