APOE and amyloidosis: These observations are compatible with the recent evidence that vascular cell adhesion molecule VCAM1 directs microglial Aβ chemotaxis by sensing amyloid plaque‐associated ApoE (Lau et al., 2023), and explain why enlarged microglial processes in our dataset seems to ignore the loose diffuse amyloid plaque shell and orient toward the fibrillar plaque core.