For example, in our study, we used OVA to establish allergic rhinitis mouse model, but many studies have shown that using dust mites to establish allergic rhinitis may be more consistent with the natural environment sensitization process.[2, 62] In the next study, we will try to use dust mites instead of OVA to establish allergic rhinitis model, so as to explore whether there are differences in the role of CD169+macrophages in different allergic rhinitis models, and whether there are new pathogenesis. This evidence concerns the gene SIGLEC1 and allergic rhinitis.