A. lumbricoides is known to be a benign infection that may not have strong effect on IFN-γ production.25 A study conducted in Venezuela reported that A. lumbricoides-modulated Th2 and IL-10 levels can increase the result of a positive TST after M. tb exposure.36 Another study in Brazil showed that A. lumbricoides infection had no impact on Th1, Th2 and Th17 responses.59 Further studies about immune modulation of helminth species and parasite intensity with large sample sizes are suggested. The gene discussed is IL10; the disease is infection.