This aligns with recent findings suggesting that both LDHA and LDHB contribute to pyruvate-to-lactate conversion, requiring the simultaneous knockout of both LDHA and LDHB to stop lactate production in LS174T (human colorectal adenocarcinoma) and B16-F10 (mouse melanoma) cell lines (54). This evidence concerns the gene LDHB and colorectal adenocarcinoma.