Naturally occurring phytosubstances can directly regulate the proliferation of estrogen-dependent as well as estrogen-independent mammary tumor cells by influencing essential mechanisms such as the inhibition of COX-2 or the modulation of key signaling pathways (Hedgehog, NF-κB, Nrf2, STAT3, Wnt and others) (63–65). Here, NFKB1 is linked to breast cancer.