Moreover, the top 10 most prevalently mutated genes in CRC (45), ie. APC, TP53, KRAS, PIK3CA, FAT4, FBXW7, CSMD3, BRAF, LRP1B and SMAD4, were all recurrently identified in our cohort (45) (Table 2). This evidence concerns the gene TP53 and colorectal carcinoma.