Moreover, the top 10 most prevalently mutated genes in CRC (45), ie. APC, TP53, KRAS, PIK3CA, FAT4, FBXW7, CSMD3, BRAF, LRP1B and SMAD4, were all recurrently identified in our cohort (45) (Table 2). Here, FAT4 is linked to colorectal carcinoma.