POLQ and hepatocellular carcinoma: Several studies have shown the association of POLQ expression with outcome in other tumor entities such breast cancer (13, 14), ovarian (7) colorectal cancer (15) or lung cancer (16), and also its relation with pathogenesis in lung adenocarcinoma (17, 18), hepatocellular carcinoma (19) and esophageal squamous cell carcinoma (20, 21).