ASCVD: Atherosclerotic Cardiovascular Disease; LDL-C: Low-Density Lipoprotein Cholesterol; HDL: High-Density Lipoprotein; Lp(a): Lipoprotein(a); LPA gene: Lipoprotein(a) gene; MESA: Multi-Ethnic Study of Atherosclerosis; TNT Trial: Treating to New Targets trial; MIRACL Trial: Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering Trial; ACS: Acute Coronary Syndrome; REVERSAL: Reversal of Atherosclerosis with Aggressive Lipid LoweringPCSK9: Proprotein Convertase Subtilisin/Kexin type 9; siRNA: small interfering Ribonucleic Acid. Here, PCSK9 is linked to myocardial ischemia.