Lp(a): Lipoprotein(a); OCEAN(a) DOSE: Olpasiran trials of Cardiovascular Events And LipoproteiN[a] reduction–DOSE Finding Study; Apo(a): Apolipoprotein(a); HORIZON: Hyperlipoproteinemia(a) Randomized Intervention Study of Drug Targeting Lp(a) and Cardiovascular Events; MACE: Major Adverse Cardiovascular Event; ASCVD: Atherosclerotic Cardiovascular Disease; CVD: Cardiovascular Disease. The gene discussed is AOPEP; the disease is cardiovascular disorder.