LPA and coronary artery disorder: The MESA study also suggested that the group of participants who had an elevated LDL-C level but in whom the Lp(a) was < 50mg/dl did not suffer from an increased lifetime risk of CHD compared to the reference group. In summary, the MESA study concluded that there was an increased risk of CHD events when Lp(a) is elevated regardless of the baseline LDL-C (even when optimal) in the setting of primary prevention [6].