Similar to previous studies for allergic rhinitis and allergic asthma,37,38 we observed that Dermatophagoides spp., was the main source of IgE sensitization in CRS; we observed that 52% of CRS patients had atopy and this group had a higher frequency of asthma, NERD, and the presence of polyps, which supports its usefulness as a potential biomarker to identify different endophenotypes. This evidence concerns the gene IGHE and allergic asthma.