IGHE and congenital rubella syndrome: Frequency of sIgE sensitization (atopy) among CRS patients diverges widely among populations.1, 2, 3 In CRS the prevalence of atopy and the role of IgE in CRS pathogenesis has been studied34, 35, 36 but little information is available about the clinical relevance of sIgE using NCT in CRS and the role of sIgE as predictor biomarker of clinical outcomes.