The enhanced immune function mediated by GLP is the core mechanism of GL's anti-tumor effect, mainly by binding to serum specific proteins or leukocyte surfaces, activating effector cells such as macrophages, natural killer cells (NK), helper T cells, and increasing the production of cytokines such as IL, interferon (IFN), TNF-a, nitrogen monoxide (NO), and antibodies, thereby enhancing the host's defense and producing anti-tumor effects [83]. Here, TNF is linked to neoplasm.