Tumor induced hypoglycemia (TIH) was mainly thought due to humoral consumption of glucose, until the elucidation of “big-IGF-II” as etiology of most NICTH cases, as elaborated by Daughaday et al. The underlying mechanism of hypoglycemia in SFT is fusion of NGFI-A–binding protein 2 (NAB2)–STAT6 resulting in over expression of IGF-II, unprocessed resulting in larger molecular weight, unbound by IGFBP, acting on IGF-I and IGF-II receptors, but also IR resulting in hypoglycemia. This evidence concerns the gene IGF2R and Hypoglycemia.