Tumor, tumor, solid, metastasis, metastatic cancer, cancer, cancer metastatic, tumors, neoplasms, neoplasm metastasis, solid tumor, advanced solid tumor, advanced cancer, malignant solid tumor, malignant solid neoplasm, malignant neoplasm, malignant tumor, TSC, TSC1, TSC2, metastatic solid tumor, metastatic neoplasm. This evidence concerns the gene TSC2 and metastatic malignant neoplasm.