Subjects were diagnosed at a median age of 6.1 years and experienced a median overall survival (OS) time of 11.7 months from diagnosis (range 3.3–43.1 months), consistent with the typical outcome for this patient population.1,4,42 All patients who underwent a tumor biopsy had H3K27M mutation testing performed (n = 24), and a majority also had TP53 mutation testing (n = 15). This evidence concerns the gene TP53 and neoplasm.