Both patients presenting RION in the absence of tumor progression had preexisting conditions prior to treatment: ANA-positive connective tissue disease and a smoking history of 15–20 pack years (ONSM-17), and cutis marmorata telangiectatica congenita and factor V Leiden with reported events of sinus venous thrombosis (ONSM-19). The gene discussed is BTG3; the disease is connective tissue disorder.