Furthermore, altered HCN-cAMP signaling in prefrontal cortex networks also appears to contribute to the working memory deficits in schizophrenia and stress (Paspalas et al., 2013; Arnsten, 2011; Gamo et al., 2015), while mutations in SHANK3 linked to schizophrenia (Gauthier et al., 2010; Guilmatre et al., 2014) may induce an HCN channelopathy (Yi et al., 2016). The gene discussed is SHANK3; the disease is schizophrenia.