The first screening with BC > 76.543, CC > 0.197, DC > 8, EC > 0.055, and LAC >2.545 yielded 29 nodes such as CXCL8, CCL2, IL6, IFNG, IL1B, CXCL2, and CXCL10; and the second screening with BC > 344.488, CC>0.200, DC>22, EC>0.189, and LAC>7.2, finally obtained a core network containing 6 nodes and 14 edges. The gene discussed is CCL2; the disease is breast cancer.