SIRT1 and obesity due to melanocortin 4 receptor deficiency: In addition, SIRT1 activation has been associated with prolonged cellular lifespan, improved metabolic health, and suppression of inflammatory responses, Quercetin can inhibit the NF kappa B pathway through activation of SIRT1, which can ameliorate obesity-induced BAT inflammation (42) and alleviate the effects of iron metamorphosis in order to prevent aging-associated diseases.