GCK and diabetes mellitus: Quercetin’s advantageous effect on blood glucose levels may be due to many mechanisms, including boosting glucose uptake through GLUT4 and boosting glucokinase activity, promoting liver absorption of glucose, and suppressing liver glycogenolysis and gluconeogenesis (40), or alleviating oxidative stress and pancreatic β-cell damage, which can play a positive role in the control of diabetes mellitus.Akt, a serine protein kinase, can control adipogenesis and lipid metabolism via influencing LDL receptors.