In an employed Apc mutant mouse lines(Apc+/min and Apc+/1638N) as a surrogate model of human CRC, an almost twofold increase in the number of tumors in mice infected with H. pylori was observed, which is consistent with the fact observed in epidemiology that people infected with H. pylori have a nearly twofold increased risk of developing CRC (6). Here, APC is linked to colorectal carcinoma.