Briefly, the IVW estimates showed that DLBCL(β:-0.003; 95% CI: -0.087–0.081; P = 0.936; FDR = 0.936), HL (β: 0.009; 95% CI: -0.007–0.025; P = 0.314; FDR = 0.523), FL (β: 0.046; 95% CI: -0.017–0.109; P = 0.148; FDR = 0.370), CLL (β: -0.006; 95% CI: -0.022–0.010; P = 0.427; FDR = 0.534) and MM (β: 0.045; 95% CI: 0.000–0.090; P = 5.00 × 10−2; FDR = 0.250) were not associated with β2M. The gene discussed is B2M; the disease is B-cell chronic lymphocytic leukemia.