However, analysis of the canonical pathways from the MsigDB C2 collection revealed that the innate immune system was more specific for DLBCL and HL than for FL, CLL, and MM, involving 17 genes, including MHC class I molecules (HLA-A, B,C, and E), complement system (C2, CFB, C4A, and C4B), heat shock protein family A (HSPA1A and HSPA1B), proteasome 20S subunit beta (PSMB8 and PSMB9), tubulin beta class I (TUBB), ATPase H+ transporting V1 subunit G2 (ATP6V1G2), casein kinase 2 beta (CSNK2B), neuraminidase 1(NEU1), and advanced glycosylation end-product specific receptor (AGER). This evidence concerns the gene C4B and B-cell chronic lymphocytic leukemia.