B2M and neoplasm: Figure 5B shows that B2M was highly upregulated in innate immune cells within typical representative tissues, particularly in natural killer cells. A similar upregulation pattern was observed for the B2M transcription factor NLRC5. This pattern was also evident in other tissue types not displayed, such as esophageal mucosa, skeletal muscle, and prostate. Furthermore, in DLBCL patient tumor tissues, NLRC5 showed significant associations not only with B2M but also with 11 genes involved in the innate immune system (Figure 5C).