1.Thiamine supplementation may be the reason of the high rate of tumor cell proliferation, survival, and resistance to chemotherapy.2. Furthermore, thiamine has been connected to cancer through its effects on reactive oxygen species, cyclooxygenase-2, prostaglandins, matrix metalloproteinases, and nitric oxide synthase.1. High-dose of RF supplementation was important in inducing cancer cells to proliferate, invade, and migrate.1. Erythema, pruritus, abnormal liver function test results, vomiting, and diarrhea are potential niacin side effects. This evidence concerns the gene PTGS2 and neoplasm.