The J-Lat 10.6 genome contains one full-length HIV-1 reporter provirus (HIV-R7/E–/GFP, based on the R7 HXB2 derivative) with the nef open reading frame (ORF) replaced by EGFP and env rendered non-functional by a frameshift mutation; it is thus incapable of productive infection.42 The gene discussed is ERVW-1; the disease is infection.