MAPT and Alzheimer disease: Alzheimer’s disease (AD), the most common type of dementia, is marked by the accumulation of extracellular amyloid-β protein (Aβ), intracellular deposition of hyperphosphorylated tau protein in neurofibrillary tangles, neuroinflammation, and lipid alterations.1 - 4 However, the molecular mechanism driving neurodegeneration in AD remains uncertain.