SHIP1 is a target of miR-155 in which miR-155 decrease the expression of SHIP-1 and it is known that SHIP-1 is a suppressor of hematopoietic transformation as its activity can inhibit the PI3K/Akt signaling pathway in acute myeloid leukemia and myelodysplastic syndromes. The gene discussed is INPP5D; the disease is acute myeloid leukemia.