As for differentiating between severe from mild COVID-19 cases, research demonstrated that key clinical markers like C-reactive protein (CRP) and D-dimer have been outperformed by SARS-CoV-2-encoded miRNA called miR-nsp3-3p, additionally, its ability in distinguishing cases at higher risk even before the appearance of severe signs, rendered it as a prognostic indicator. This evidence concerns the gene CRP and COVID-19.