Multiple studies have demonstrated that CST3 plays a protective role in the brain [26,27], possibly through pathways associated with autophagy or inhibition of cysteine proteases [28,29]; however, the relationship between CST3 and hyperbilirubinemia, and the function of exosomes in hyperbilirubinemia is unclear. This evidence concerns the gene CTSB and Hyperbilirubinemia.