Remarkably, our knockdown of METTL16 significantly promoted tumor cell growth in both organoid (Fig. 3A, B) and pancreatic cancer cell lines (P<0.01) (Supplementary Fig. S1C, D, Supplemental Digital Content 2, http://links.lww.com/JS9/D517). Here, METTL16 is linked to familial pancreatic carcinoma.