METTL16 and neoplasm: Conversely, when we overexpressed METTL16 (Supplementary Fig. S1E, F, Supplemental Digital Content 2, http://links.lww.com/JS9/D517), we observed a significant inhibition of tumor growth (Fig. 3C, D and Supplementary Fig. S1G, H, Supplemental Digital Content 2, http://links.lww.com/JS9/D517).