These mutant transgenic mice had ductal shaped preinvasive pancreatic neoplastic lesions, indicating the implication of Kras mutations in the onset of pancreatic ductal carcinoma.[24] Another study involved mating of LSL‐KrasG12D allele‐carrying mice with either transgenic Ptf1a‐Cre mice or Pdx1‐Cre mice. Here, KRAS is linked to pancreatic ductal adenocarcinoma.