But, somatic PIK3CA mutations have frequently been observed in pancreatic intraductal tubular papillary neoplasm (ITPN), an uncommon subtype of premalignant pancreatic lesion that differs from intraductal papillary mucinous neoplasm (IPMN).[33, 34, 35] However in an earlier study, two mouse models were produced that expressed pancreatic PIK3CA that was constitutively active. The gene discussed is PIK3CA; the disease is pancreatic intraductal papillary-mucinous neoplasm.