STK11 and neoplasm: LKB1/STK11 (liver kinase B1/serine‐threonine kinase 11) encodes an important serine‐threonine kinase and controls downstream kinases that are involved in the regulation of cellular response to energy stress and the development of cell polarity.[49] LKB1 was first discovered as a tumour suppressor gene linked to Peutz‐Jegher Syndrome (PJS).[50] PJS patients had a 132‐fold higher chance of acquiring pancreatic cancer than the general population.[51] About 4–25 % of IPMN harbour the deleterious mutation of LKB1.