In the AD group (3xTg), the ratio of p‐JNK/JNK was significantly decreased (Figure 5k,l; p < 0.01, t‐test; n = 6) while the level of SOX2 was increased compared to the control group (C57BL/6 and SAMR1) (Figure 5k,l, and Figure S1a–c; p < 0.05, t‐test; n = 6). The gene discussed is MAPK8; the disease is Alzheimer disease.