Furthermore, apelin and others were positively correlated with pathways like the PI3K‐AKT signalling pathway as well as the WNT signalling pathway, which were linked to tumour progression and proliferation, while KLF2, SAMD2, AKT1 and SERPINE1 were closely related to the NF‐κB signalling pathway, the IL‐2‐STAT5 signalling pathway, and the Hypoxia tumour validation pathway (Figure 8B). The gene discussed is APLN; the disease is neoplasm.