Under hypoxic conditions, BC cells increase neutrophil infiltration in the TME by signaling molecules such as lncRNAs and chemokines, including the chemokine C-X-C motif ligand 1–3 (CXCL1-3), CXCL5-8, and CXCL12, and some lncRNAs have been demonstrated to be transported from BC cells to neutrophils through EVs [48, 49]. The gene discussed is XCL1; the disease is breast cancer.