Additionally, autophagy-associated adhesion G protein-coupled receptor G2 (GPR64) is enriched in hypoxic CAF-EVs, which stimulate noncanonical NF-κB signaling to upregulate the expression of MMP-9 and IL-8 in recipient BC cells, enhancing the invasive ability of BC cells [65]. The gene discussed is ADGRG2; the disease is breast cancer.