When we compared our list of significantly increased brain microvessel proteins to that of a recently published DIA proteomic analysis of inferior parietal lobe bulk tissue using the same methodology in subjects with or without AD [27], we found that A4, midkine (MK), SPARC related modular calcium binding 1 (SMOC1), neuroepithelial cell-transforming gene 1 protein (NET1), Glutathione S-transferase omega-1 (GSTO1), and platelet-activating factor acetylhydrolase IB subunit alpha1 (PA1B3) were common proteins that were found to be significantly increased in both datasets. The gene discussed is MDK; the disease is Alzheimer disease.