Meanwhile, EPHX4, IL13RA1, PMFBP1, TIMD4, AHCYL1, IGKV4-1, LGALS3BP, PRKCSH, APOF, and F9 exhibited significant dysregulation in the B3 vs. MTC comparison. The gene discussed is IGKV4-1; the disease is medullary thyroid gland carcinoma.