But using the levels of CEACAM4 in the HD fraction as a reference for PLAC8, also a SeptiCyteTM LAB gene, and CD63 in the LD fraction still improved the sepsis-SIRS distinction by these two azurophilic granule genes compared to their unreferenced LD levels (Fig. 7C). Here, CEACAM4 is linked to systemic inflammatory response syndrome.