CTSA and systemic inflammatory response syndrome: Notably, the only granule biogenesis pathway genes, known to be restricted to these two earliest precursor stages [25] and indeed represented in the LD granulocytes, were CTSA and CD63 (both Azurophilic Granules) in the sepsis versus SIRS comparison, and CTSA and LAIR1 (the latter Specific Granules) in the septic shock versus SIRS comparison.