PLAC8 and systemic inflammatory response syndrome: These were the promyelocyte-restricted Azurophilic Granule pathway genes LAMP1 and PLAC8 as well as the PMN-restricted Cell Membrane pathway genes CEACAM4 and PLA2G7. LAMP1 and PLAC8 both appeared more highly expressed in LD than total granulocytes of SIRS patients and in LD than HD granulocytes in sepsis patients (Fig. 5), consistent with granulocyte precursors as their source, but no patient subgroup differences were seen for either gene (Fig. 6).