One of the multiple activities of PLAC8 may account for differences in the control of its developmental and potentially also inducible expression compared to CD63. This may explain elevated and prolonged activation of PLAC8 up to the PMN stage in sepsis, while the elevated sepsis levels of CD63, encoding a mediator of protein trafficking to azurophilic granules, remains restricted to immature granulocytes. The gene discussed is PLAC8; the disease is Sepsis.