We focused on the outer mitochondrial membrane (OMM) protein mitofusin 2 (MFN2), because its ablation impairs OXPHOS and mutations in MFN2 in humans are associated with lipodystrophies and an axonal neuropathy known as Charcot-Marie-Tooth Disease type 2A (Capel et al, 2018; Chen et al, 2007; Pich et al, 2005; Rocha et al, 2017). The gene discussed is MFN2; the disease is Charcot-Marie-Tooth disease type 2A1.