SMC4 and neoplasm: Given that depletion of both YY1 and KDM5C led to significant suppression of tumor cell proliferation (Fig. 4), we next investigated the gene expression patterns by analyzing the RNA-seq results and found that the expression of several cell cycle- and cell apoptosis-related genes, including JAM3, KNTC1, SMC2, SMC4, LMNB1 and FOXM1, was markedly downregulated in the double-knockdown cell group (Fig. 5E).