YY1 and renal carcinoma: To achieve this goal, we first selected human kidney proximal tubular epithelial cell line (HK-2), and several renal cancer cell lines (ACHN, 769-P and RCC4) with different KDM5C and YY1 protein expression levels, as described in our previous studies (Chen et al, 2018; Zheng et al, 2021) (Fig. 2A).