Indeed, a systemic The Cancer Genome Atlas (TCGA) clinical data-based analysis clearly revealed that high KDM5C expression was positively or negatively correlated with cancer patient survival, depending on the cancer type (Fig. 1A), reinforcing the idea that KDM5C may exhibit a distinct regulatory effect on gene expression, prompting us to screen the interacting partners of KDM5C. Here, KDM5C is linked to cancer.