ANXA5 and central nervous system cancer: To elucidate whether OLA sensitizes high-grade glioma cells to radiation alone, or more broadly to DNA damaging insults (TMZ or ETOP), flow cytometry was used to quantify proportions of early (AnnexinV + ) and late (AnnexinV+ Propidium Iodide (PI) +) apoptotic/necrotic cells.