Considering the central roles of GPIbα and E+ integrin αIIbβ3 in biomechanical platelet aggregation12, these results explain the intensified biomechanical thrombogenesis observed in hypertension patients’ blood, and suggest that GPIbα-integrin αIIbβ3 mechanosensing axis hyperactivity directly contributes to the high incidence rate of CVD in hypertension patients. Here, GP1BA is linked to hypertensive disorder.