The causes of GPIbα and integrin αIIbβ3 hyperactivity in hypertension patients as well as the similar trend of platelet hyperreactivity in older people warrant further investigation, which are possibly relevant to hypertension/aging-associated oxidative stress and inflammation that cause platelet pre-activation65–67, dysregulated glycosylation of GPIbα and integrin αIIbβ3 by metabolic disorders68,69, and/or the activation of mechanosensitive ion channel Piezo1 that causes platelet hyper-sensitivity to shear force16. This evidence concerns the gene PIEZO1 and hypertensive disorder.